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Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophilaopen access

Authors
Sinenko, Sergey A.Shim, JiwonBanerjee, Utpal
Issue Date
Jan-2012
Publisher
Nature Publishing Group
Keywords
FoxO; haematopoietic niche; haemocyte; ROS; Spitz
Citation
EMBO Reports, v.13, no.1, pp.83 - 89
Indexed
SCIE
SCOPUS
Journal Title
EMBO Reports
Volume
13
Number
1
Start Page
83
End Page
89
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/166444
DOI
10.1038/embor.2011.223
ISSN
1469-221X
Abstract
Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor-like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses.
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