Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study
- Authors
- Lee, Yong Seop; Tae, Kyung; Lee, Seung Hwan; Cho, Seok Hyun; Jeong, Jin Hyeok; Min, Hyun Jung; Ji, Yong Bae
- Issue Date
- Oct-2011
- Publisher
- SPRINGER
- Keywords
- Telomerase; Head and neck cancer
- Citation
- CLINICAL & TRANSLATIONAL ONCOLOGY, v.13, no.10, pp.747 - 752
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL & TRANSLATIONAL ONCOLOGY
- Volume
- 13
- Number
- 10
- Start Page
- 747
- End Page
- 752
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167534
- DOI
- 10.1007/s12094-011-0727-5
- ISSN
- 1699-048X
- Abstract
- Background The purpose of this study was to evaluate telomerase activity in peripheral whole blood from head and neck squamous cell carcinoma (HNSCC) patients as a biomarker for diagnosis of HNSCC or detection of recurrence during follow-up. Materials and methods Telomerase activity was measured from peripheral whole blood extracts by telomerase repeat amplification protocol (TRAP) in HNSCC patients before and after surgery and in a control group. Sixty-two HNSCC patients and 42 control subjects were included. Results Telomerase activity was found in 41 out of 62 (66.1%) HNSCC patients before surgery and in 8 out of 42 (19.0%) controls (p<0.001). Among 41 HNSCC patients who showed positive telomerase activity before surgery, 32 (78.1%) showed a conversion of telomerase activity to negative after surgery. In follow-up, 6 out of 8 (75%) showed conversion of telomerase activity from negative to positive after recurrence. Telomerase activity was changed to negative in 4 out of 6 (66%) recurred patients with positive telomerase activity after second surgery. Conclusion The telomerase activity in peripheral whole blood extracts of HNSCC patients might be a useful biomarker for detecting recurrence after treatment. Further study with larger sample size using a more sensitive detection method of telomerase activity is necessary to verify these results.
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