Sonoelastographic lesion stiffness: preoperative predictor of the presence of an invasive focus in nonpalpable DCIS diagnosed at US-guided needle biopsy
- Authors
- Cho, Nariya; Moon, Woo Kyung; Chang, Jung Min; Yi, Ann; Koo, Hye Ryoung; Park, Jeong-Seon; Park, In Ae
- Issue Date
- Aug-2011
- Publisher
- SPRINGER
- Keywords
- Breast; US; Breast neoplasms; Diagnosis; Ultrasound (US); Elastography; Ultrasound (US); Tissue characterization
- Citation
- EUROPEAN RADIOLOGY, v.21, no.8, pp.1618 - 1627
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN RADIOLOGY
- Volume
- 21
- Number
- 8
- Start Page
- 1618
- End Page
- 1627
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167844
- DOI
- 10.1007/s00330-011-2103-9
- ISSN
- 0938-7994
- Abstract
- To retrospectively evaluate whether sonoelastographic evaluation could help predict the presence of an invasive focus in nonpalpable DCIS diagnosed at US-guided needle biopsy. One hundred and three consecutive nonpalpable DCIS lesions diagnosed at US-guided needle biopsy were analyzed. To identify the preoperative factors associated with upgrade to invasive cancers on surgical histology, lesion size, B-mode US findings, elasticity score, biopsy variables, and histological variables were analyzed using univariate and multivariate logistic regression. Interobserver agreement for the elasticity score was evaluated using the multi-rater kappa statistics. The overall upgrade rate was 23% (24 of 103). Elasticity score was found to be the only independent predictor of invasion. The upgrade rates according to the median elasticity score was 6.7% (1 of 15) for a score of 1, 20.6% (13 of 63) for a score of 2, and 40.0% (10 of 25) for a score of 3 (Odds ratio [OR] = 1; OR = 4.19, P = 0.207; OR = 12.32, P = 0.039, respectively). No association was found between other factors and the upgrade rate. The overall interobserver agreement for the elasticity score was moderate (kappa = 0.587; P < .001). Sonoelastographic lesion stiffness is an independent preoperative predictor of invasion in some patients with nonpalpable DCIS at US-guided needle biopsy.
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