XRCC1 Polymorphisms and Risk of Papillary Thyroid Carcinoma in a Korean Sampleopen access
- Authors
- Ryu, Ri A.; Tae, Kyung; Min, Hyun Jung; Jeong, Jin Hyeok; Cho, Seok Hyun; Lee, Seung Hwan; Ahn, You Hern
- Issue Date
- Aug-2011
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Polymorphisms; XRCC1; SNP; Papillary Thyroid Carcinoma; Susceptibility
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.8, pp.991 - 995
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 26
- Number
- 8
- Start Page
- 991
- End Page
- 995
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/167910
- DOI
- 10.3346/jkms.2011.26.8.991
- ISSN
- 1011-8934
- Abstract
- Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers. We analyzed the relationship between XRCC1 polymorphisms and the risk of papillary thyroid carcinoma in a Korean sample. A hospital-based case-control study was performed in 111 papillary thyroid carcinoma patients and 100 normal control subjects. XRCC1 Arg194Trp and Arg399Gln single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.9831). There was no significant association between XRCC1 Arg399Gln genotypes and risk of papillary thyroid carcinoma. Based on these results, the XRCC1 Arg194Trp Arg/Trp genotype could be used as a useful molecular biomarker to predict genetic susceptibility for papillary thyroid carcinoma in Koreans.
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