Cortical Thinning in Verbal, Visual, and Both Memory-predominant Mild Cognitive Impairment
- Authors
- Kim, Min-Jeong; Im, Kiho; Lee, Jong-Min; Park, Aram; Chin, Juhee; Kim, Geon Ha; Kim, Jong Hun; Roh, Jee Hoon; Seo, Sang Won; Na, Duk L.
- Issue Date
- Jul-2011
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- amnestic mild cognitive impairment; verbal memory; visual memory; cortical thickness; magnetic resonance imaging; Alzheimer disease
- Citation
- Alzheimer Disease & Associated Disorders, v.25, no.3, pp.242 - 249
- Indexed
- SCIE
SCOPUS
- Journal Title
- Alzheimer Disease & Associated Disorders
- Volume
- 25
- Number
- 3
- Start Page
- 242
- End Page
- 249
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168061
- DOI
- 10.1097/WAD.0b013e3182076d31
- ISSN
- 0893-0341
- Abstract
- The amnestic form of mild cognitive impairment (aMCI) is likely a precursor of Alzheimer disease (AD). Both verbal and visual memory tests are used in the diagnosis of aMCI; however, it is unknown which type of test is superior at predicting the underlying pathologic changes associated with AD. In this study, we compared the topography of cortical thinning among 3 subtypes of patients with aMCI: 33 patients with predominant verbal memory impairment (verbal-aMCI), 35 with predominant visual memory impairment (visual-aMCI), and 56 with both verbal and visual memory-predominant impairment (both-aMCI), and 143 patients with normal cognition. As a result, patients with verbal-aMCI showed cortical thinning in the left anterior and medial temporal regions compared with individuals with normal cognition, while those with visual-aMCI did not show significant cortical thinning. The cortical thinning areas of both-aMCI group overlapped those of verbal-aMCI but were more widespread involving the bilateral temporal regions. These findings suggest that the verbal-aMCI and both-aMCI are more likely to be a precursor of AD than visual-aMCI, and that both-aMCI may be more advanced subtype than verbal-aMCI on the spectrum from MCI to AD.
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