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Expression of activated HER2 in human testes
- Authors
- Shin, Inchoel; Kim, Hyun Joo; Nah, Won Heum; Park, Hyun Jun; Gye, Myung Chan; Park, Hae Young
- Issue Date
- Jun-2011
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Germ cells; HER2; human; soma; testis; tyrosine phosphorylated
- Citation
- FERTILITY AND STERILITY, v.95, no.8, pp.2725 - 2728
- Indexed
- SCIE
SCOPUS
- Journal Title
- FERTILITY AND STERILITY
- Volume
- 95
- Number
- 8
- Start Page
- 2725
- End Page
- 2728
- ISSN
- 0015-0282
- Abstract
- The her2 messenger RNA (mRNA) was the most abundant among the erb type-1 tyrosine kinase receptors mRNA in human testis and was statistically significantly decreased in impaired spermatogenesis. Testicular HER2 was tyrosine phosphorylated and strongly expressed in spermatogonia, early spermatocytes, elongating/elongated spermatids, Sertoli cells, Leydig cells, and peritubular cells, suggesting that activated HER2 participates in mitosis and meiotic entry of germ cells, spermiogenesis, and steroidogenesis via mediating the epidermal growth factor-growth factor signaling.
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Related Researcher
- Gye, Myung Chan
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF LIFE SCIENCE)