DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans
- Authors
- Son, Le Tho; Ko, Kyung-Min; Cho, Jeong Hoon; Singaravelu, Gunasekaran; Chatterjee, Indrani; Choi, Tae-Woo; Song, Hyun-Ok; Yu, Jae-Ran; Park, Byung-Jae; Lee, Sun-Kyung; Ahnn, Joohong
- Issue Date
- May-2011
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- dhs-21; L-Xylulose reductase; Longevity; Egg-laying; Gene expression
- Citation
- FEBS LETTERS, v.585, no.9, pp.1310 - 1316
- Indexed
- SCIE
SCOPUS
- Journal Title
- FEBS LETTERS
- Volume
- 585
- Number
- 9
- Start Page
- 1310
- End Page
- 1316
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168568
- DOI
- 10.1016/j.febslet.2011.03.062
- ISSN
- 0014-5793
- Abstract
- Dicarbonyl/L-xylulose reductase (DCXR) converts L-xylulose into xylitol, and reduces various a-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification. In this study, we identified DHS-21 as the only DCXR ortholog in Caenorhabditis elegans. The dhs-21 gene is expressed in various tissues including the intestine, gonadal sheath cells, uterine seam (utse) cells, the spermathecal-uterus (sp-ut) valve and on the plasma membrane of spermatids. Recombinant DHS-21 was shown to convert L-xylulose to xylitol using NADPH as a cofactor. Dhs-21 null mutants of C. elegans show defects in longevity, reproduction and egg-laying. Knock-down of daf-16 and elt-2 transcription factors affected dhs-21 expression. These results suggest that DHS-21 is a bona fide DCXR of C. elegans, essential for normal life span and reproduction.
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