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The Effect of Conjugating RGD into 3D Alginate Hydrogels on Adipogenic Differentiation of Human Adipose-Derived Stromal Cells
- Authors
- Kang, Sun-Woong; Cha, Byung-Hyun; Park, Honghyun; Park, Kwang-Sook; Lee, Kuen Yong; Lee, Soo-Hong
- Issue Date
- May-2011
- Publisher
- John Wiley & Sons Ltd.
- Keywords
- adhesion; biological applications of polymers; biomaterials; hydrogels; tissue engineering
- Citation
- Macromolecular Bioscience, v.11, no.5, pp 673 - 679
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Macromolecular Bioscience
- Volume
- 11
- Number
- 5
- Start Page
- 673
- End Page
- 679
- ISSN
- 1616-5187
1616-5195
- Abstract
- The effects of RGD peptide conjugation to alginate hydrogel on the adipogenic differentiation of ASCs was investigated. After 3 d of culture, RGD-modified alginate hydrogels significantly stimulated FAK and integrin alpha 1 gene expressions and vinculin expression in ASCs. In addition, RGD-modified alginate hydrogels significantly enhanced the adipogenic differentiation of human ASCs to exhibit higher expression levels of oil red O staining and adipogenic genes compared to those of the control group (unmodified gels). These results suggest potential applications of RGD-modified alginate gels for adipose tissue regeneration.
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Related Researcher
- Lee, Kuen Yong
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)