Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas
- Authors
- Jun, Young Jin; Jang, Se Min; Han, Hu Lin; Lee, Kang Hong; Jang, Ki-Seok; Paik, Seung Sam
- Issue Date
- Apr-2011
- Publisher
- BAISHIDENG PUBLISHING GROUP INC
- Keywords
- Adenocarcinoma; Colorectum; Glucose transporter-1; Apoptosis-activating factor-1; Prognosis; Survival
- Citation
- WORLD JOURNAL OF GASTROENTEROLOGY, v.17, no.14, pp.1866 - 1873
- Indexed
- SCIE
SCOPUS
- Journal Title
- WORLD JOURNAL OF GASTROENTEROLOGY
- Volume
- 17
- Number
- 14
- Start Page
- 1866
- End Page
- 1873
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168755
- DOI
- 10.3748/wjg.v17.i14.1866
- ISSN
- 1007-9327
- Abstract
- AIM: To investigate the role of glucose transporter 1 (GLUT1) expression in colorectal carcinogenesis and evaluate the correlation with clinicopathological parameters and apoptosis-activating factor-1 (Apaf-1) expression in colorectal adenocarcinomas. METHODS: We used tissue microarrays consisting of 26 normal mucosa, 50 adenomas, 515 adenocarcinomas, and 127 metastatic lesions. Medical records were reviewed and clinicopathological analysis was performed. RESULTS: GLUT1 expression was absent in normal mucosa and low or moderately apparent in 19 cases (38.0%) of 50 adenomas. However, GLUT1 expression was detected in 423 (82.1%) of 515 adenocarcinomas and in 96 (75.6%) of 127 metastatic lesions. GLUT1 expression was significantly correlated with female gender (P = 0.009), non-mucinous tumor type (P = 0.045), poorer differentiation (P = 0.001), lymph node metastasis (P < 0.001), higher AJCC and Dukes stage (P < 0.001 and P < 0.001, respectively). There was a significant inverse correlation between GLUT1 expression and Apaf-1 expression (P = 0.001). In univariate survival analysis, patients with GLUT1 expression demonstrated poor overall survival and disease-free survival (P = 0.047 and P = 0.021, respectively, log-rank test). CONCLUSION: GLUT1 expression was frequently increased in adenocarcinomas and metastatic lesions. GLUT1 expression was significantly correlated with poorer clinicopathologic phenotypes and survival of patients with colorectal adenocarcinomas.
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