Brief review of the role of glycogen synthase kinase-3β in amyotrophic lateral sclerosisopen access
- Authors
- Koh, Seong-Ho; Baek, Wonki; Kim, Seung H
- Issue Date
- Mar-2011
- Publisher
- Hindawi Publishing Corporation
- Citation
- Neurology Research International, v.2011, pp.1 - 5
- Indexed
- SCOPUS
- Journal Title
- Neurology Research International
- Volume
- 2011
- Start Page
- 1
- End Page
- 5
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/168966
- DOI
- 10.1155/2011/205761
- ISSN
- 2090-1852
- Abstract
- Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenicmechanisms inmotor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.
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