Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients
- Authors
- Bang, So-Young; Kim, Tae-Hwan; Lee, Bitnara; Kwon, Eunji; Choi, Sang Hyun; Lee, Ki Soo; Shim, Seung Cheol; Pope, Angela; Rahman, Proton; Reveille, John D.; Inman, Robert D.
- Issue Date
- Feb-2011
- Publisher
- J RHEUMATOL PUBL CO
- Keywords
- ANKYLOSING SPONDYLITIS; ERAP1; 2p15; KOREA; SINGLE-NUCLEOTIDE POLYMORPHISM
- Citation
- JOURNAL OF RHEUMATOLOGY, v.38, no.2, pp.322 - 324
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF RHEUMATOLOGY
- Volume
- 38
- Number
- 2
- Start Page
- 322
- End Page
- 324
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169156
- DOI
- 10.3899/jrheum.100652
- ISSN
- 0315-162X
- Abstract
- Objective. Investigators from the Australo-Anglo-American Spondyloarthritis Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22. We evaluated these new candidate genes in a large cohort of Korean patients with AS. Methods. A group of 1164 patients with AS and 752 healthy controls were enrolled for our study. Eight single-nucleotide polymorphisms (SNP) were analyzed to define genetic association with AS by MassARRAY system. Results. Significant positive associations of AS with endoplasmic reticulum aminopeptidase 1 SNP, rs27037 (p = 1.31 x 10(-4)), and rs27434 (p = 4.59 x 10(-6)), were observed. The rs10865331 of gene desert at 2p15 also showed a significant association with AS (p = 4.63 x 10(-5)). Conclusion. This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS. (First Release Nov 1 2010; J Rheumatol 2011; 38:322-4; doi:10.3899/jrheum.100652)
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