Dysadherin can enhance tumorigenesis by conferring properties of stem-like cells to hepatocellular carcinoma cells
- Authors
- Park, Jeong-Ran; Kim, Ran-Ju; Lee, Yoo-Kyung; Kim, Soo-Rim; Roh, Kyung-Jin; Oh, Seung Hyun; Kong, Gu; Kang, Kyung-Sun; Nam, Jeong-Seok
- Issue Date
- Jan-2011
- Publisher
- ELSEVIER
- Keywords
- Dysadherin; Hepatocellular carcinoma; Cancer stem cell; Side population
- Citation
- JOURNAL OF HEPATOLOGY, v.54, no.1, pp.122 - 131
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF HEPATOLOGY
- Volume
- 54
- Number
- 1
- Start Page
- 122
- End Page
- 131
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/169257
- DOI
- 10.1016/j.jhep.2010.06.026
- ISSN
- 0168-8278
- Abstract
- Background & Aims: Hepatocellular carcinoma (HCC) is associated with a high potential for metastasis and disease recurrence, even after surgical resection. The cancer stem cell (CSC) hypothesis proposes that CSCs are responsible for chemo-resistance, recurrence, and metastasis. Dysadherin is a prognostic indicator of metastasis and poor survival in many different cancer types. In this study, we investigated the possible link between dysadherin and CSC in HCC. Methods: We analyzed the functional implications of dysadherin on cancer sternness by modification of the dysadherin gene in HCC cell lines. Results: The transfection of dysadherin cDNA into the liver cancer cell line PLC/PRF/5 enhanced the properties of CSCs, including anti-apoptosis, their sphere-forming ability, side population phenotype, and tumor initiation ability in vivo. Furthermore, knockdown of dysadherin in the liver cancer cell line SK-Hep1 suppressed its stem cell-like properties. Conclusions: These results show that dysadherin give rise to properties of CSC in HCC. Therefore, these findings suggest that dysadherin may be a potential molecular prognostic marker of HCC and may aid in the development of more effective therapies.
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