Inhibitory Effect of Ethyl Acetate Extract of White Peach Pericarp on Adipogenesis of 3T3-L1 Preadipocyte Cells
- Authors
- Park, Hong Gyu; Kim, Jin Moon; Kim, Jung Mogg; Chung, Won-Yoon; Yoo, Yun-Jung; Cha, Jeong-Heon
- Issue Date
- Dec-2008
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- Prunus persica; peach; obesity; C3H10T1/2; 3T3-L1
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.17, no.6, pp.1327 - 1331
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 17
- Number
- 6
- Start Page
- 1327
- End Page
- 1331
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/171745
- ISSN
- 1226-7708
- Abstract
- In order to determine whether peach contains compounds to regulate adipocyte differentiation, extracts of flesh/pericarp of yellow/white peach were prepared in water, ethyl acetate (EtOAc), or n-butanol solvent and determined for effects on adipocyte differentiation in C3H10T1/2 or 3T3-L1 cells. Interestingly, none of peach extracts has statistically significant stimulatory effect on the adipocyte differentiation in C3H10T1/2. Furthermore, the presence of EtOAc extract of white peach pericarp (WPP) was found to inhibit lipid accumulation in 3T3-L1 cells both by microscopic examination of Oil Red O-stained lipid droplets and by spectrophotometric quantification of extracted stain, indicating a significant inhibitory effect on adipocyte differentiation. The inhibition of lipid accumulation was accompanied by a significant decrease in the expression levels or adipocyte molecular markers-peroxisome proliferator-activated receptor gamma, CAAT enhancer binding protein alpha, and fatty acid-binding protein. Thus, this study determined that WPP EtOAc extract contains the inhibitory compound(s) on adipogenesis.
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