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升麻葛根湯의 항히스타민 효과 및 IL-4와 GM-CSF 발현에 미치는 영향Anti-histamic Effect and IL-4 and GM-CSF mRNA Expression on Sungmagalkuntang
- Other Titles
- Anti-histamic Effect and IL-4 and GM-CSF mRNA Expression on Sungmagalkuntang
- Issue Date
- Apr-2006
- Publisher
- 대한한방소아과학회
- Keywords
- Sungmagalkun-tang(SGT); Anti-histamic Effect; IL-4; GM-CS; Sungmagalkun-tang(SGT); Anti-histamic Effect; IL-4; GM-CS
- Citation
- 대한한방소아과학회지, v.20, no.1, pp 69 - 83
- Pages
- 15
- Indexed
- KCICANDI
- Journal Title
- 대한한방소아과학회지
- Volume
- 20
- Number
- 1
- Start Page
- 69
- End Page
- 83
- Abstract
- Objectives : We investigated the effect of Sungmagalkuntang(SGT) on the allergy. Methods : We conformed compound 48/80-induced active systemic anaphylatic shock, anti- dinitrophenyl IgE-mediated passive cutaneous anaphylaxis and ovalbumin-induced anaphylatic shock. Also observed IL-4 and GM-CSF mRNA expression in ovalbumin-induced allergic lung tissue and RBL-2H3. Histamine release is measured in RBL-2H3. Results : SGT inhibited active systemic anaphylatic shock, passive cutaneous anaphylaxis and ovalbumin-induced anaphylatic shock by oral administration. We observed that SGT was concentration-dependently reduced IL-4 and GM-CSF mRNA expression in ovalbumin-induced allergic lung tissue and RBL-2H3 by SGT. In addition, SGT reduced histamine release in RBL-2H3. Conclusions : These results indicate that SGT has anti-histamic effect and controls IL-4 and GM-CSF mRNA expression on allergy.
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Collections - 서울 의과대학 > 서울 교육협력지원교실 > 1. Journal Articles
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