12-OAHSA is a component of olive oil and mitigates obesity-induced inflammation
- Authors
- Moyo, Knowledge Mudhibadhi; Choi, Jieun; Chang, Jiyeon; Soedono, Shindy; Nguyet, Dan Vo Hoang; Song, Yu-Ri; Park, Soo Jin; Go, Gwang-Woong; Lee, Do Yup; Cho, Kae Wona
- Issue Date
- Dec-2022
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- FAHFA; LC-MS/MS; 12-OAHSA; Olive oil; Adipose tissue inflammation
- Citation
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY, v.110, pp.1 - 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Volume
- 110
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/172801
- DOI
- 10.1016/j.jnutbio.2022.109127
- ISSN
- 0955-2863
- Abstract
- Fatty acid esters of hydroxyl fatty acids (FAHFAs) are a new family of endogenous lipids that exert anti-inflammatory action. Among the various FAHFA isomers, the dietary source of oleic acid-hydroxy stearic acid (OAHSA) and its anti-inflammatory functions are poorly understood. This study investigated the composition of OAHSA isomers in dietary oils and the impact of 12-OAHSA on obesity-induced inflammation. Liquid chromatography with tandem mass spectrometry analysis revealed that various dietary oils, including fish oil, corn oil, palm oil, soybean oil, and olive oil, present a wide variation in OAHSA profiles and amounts. The highest amounts of total OAHSAs are present in olive oil including 12-OAHSA. Compared to vehicle-treated obese mice, administration of 12-OAHSA significantly improved glucose homeostasis, independent of body weight. 12-OAHSA-treated mice displayed significantly reduced accumulation of CD11c+ adipose tissue macrophages, and CD4+/CD8+ adipose tissue T lymphocytes. Concomitantly, the expression of pro-inflammatory cytokine genes and the nuclear factor kappa-light-chain-enhancer of activated B cells signaling pathway were significantly decreased in the 12-OAHSA-treated adipose tissue, while the expression of the anti-inflammatory gene Il10 was markedly increased. Moreover, in vitro cell culture experiments showed that 12-OAHSA significantly inhibited the lipopolysaccharides-induced inflammatory response in macrophages by suppressing the nuclear factor kappa-light-chain-enhancer of activated B cells signaling pathway. Collectively, these results indicated that 12-OAHSA, as a component of olive oil, mitigates obesity-induced insulin resistance by regulating AT inflammation. Therefore, 12-OAHSA could be used as a novel nutritional intervention against obesity-associated metabolic dysregulation.
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