Calcineurin Regulates Coelomocyte Endocytosis via DYN-1 and CUP-4 in Caenorhabditis elegans
- Authors
- Song, Hyun-Ok; Lee, Jungsoo; Ji, Yon Ju; Dwivedi, Meenakshi; Cho, Jeong Hoon; Park, Byung-Jae; Ahnn, Joohong
- Issue Date
- Sep-2010
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- Ca2+ signaling; C. elegans; endocytosis; phosphatase
- Citation
- MOLECULES AND CELLS, v.30, no.3, pp.255 - 262
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULES AND CELLS
- Volume
- 30
- Number
- 3
- Start Page
- 255
- End Page
- 262
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174162
- DOI
- 10.1007/s10059-010-0116-x
- ISSN
- 1016-8478
- Abstract
- C. elegans coelomocytes are macrophage-like scavenger cells that provide an excellent in vivo system for the study of clathrin-mediated endocytosis. Using this in vivo system, several genes involved in coelomocyte endocytosis have been identified previously. However, the detailed mechanism of endocytic pathway is still unknown. Here, we report a new function of calcineurin, an evolutionarily conserved Ca2+/calmodulin-dependent Ser/Thr protein phosphatase, in coelomocyte endocytosis. We found that calcineurin mutants show defective coelomocyte endocytosis. Genetic analysis suggests that calcineurin and a GTPase, dynamin (DYN-1), may function upstream of an orphan receptor, CUP-4, to regulate endocytosis. Therefore, we propose a model in which calcineurin may regulate coelomocyte endocytosis via DYN-1 and CUP-4 in C. elegans.
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