Clinical efficacy and tolerance of 1% nadifloxacin cream in the treatment of mild to moderate acne vulgaris in South Korea경증 및 중등도의 한국인 여드름 환자에서 1% Nadifloxacin 크림(Nadixa(R))의 유효성 및 안전성 평가
- Other Titles
- 경증 및 중등도의 한국인 여드름 환자에서 1% Nadifloxacin 크림(Nadixa(R))의 유효성 및 안전성 평가
- Authors
- Choi, Won Jun; Kim, Kwang Joong; Kim, Nack In; Kye, Young Chul; Suh, Dae Hun; Lee, Joo Heung; Kim, Myeung Nam; Lee, Eun So; Lee, Ju Hee; Ro, Young Suck
- Issue Date
- Aug-2010
- Publisher
- 대한피부과학회
- Keywords
- 1% nadifloxacin cream; Acne; Treatment
- Citation
- Korean Journal of Dermatology, v.48, no.8, pp.665 - 671
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Dermatology
- Volume
- 48
- Number
- 8
- Start Page
- 665
- End Page
- 671
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174325
- ISSN
- 0494-4739
- Abstract
- Background: Antimicrobials have been a mainstay of inflammatory acne treatment for more than 30 years. However, antibiotic-resistant propionibacteria had been isolated with increased frequency, and associated with failure to respond to antibiotic therapy. Objective: The aim of this study was to investigate the clinical efficacy and tolerance of 1% nadifloxacin cream. Methods: In the final analysis, 197 patients with mild to moderate facial acne vulgaris were enrolled. The patients were instructed to apply 1% nadifloxacin cream twice daily to the affected skin after washing the face. Following 2 and 4 weeks of treatment, patients were observed for clinical response: number of the acne lesions, Korea acne grading system (KAGS), global improvement, and occurrence of adverse reactions. Results: During 4 weeks of treatment, nadifloxacin caused significant reduction in the number of inflamed papulo-pustular lesions and open/closed comedones. In addition, significant reduction of KAGS was observed. About 96% of patients showed clinical improvement in the overall evaluation of the therapeutic effect by physicians. All reported adverse events were mild. Conclusion: This study shows that 1% nadifloxacin cream can be an effective and safe treatment for mild to moderate acne vulgaris.
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