Elevated c-Src and c-Yes expression in malignant skin cancersopen access
- Authors
- Lee, Jang Hyun; Pyon, Jae-Kyung; Kim, Dong Wook; Lee, Sang Han; Nam, Hae Seon; Kim, Chul Han; Kang, Sang Gue; Lee, Yoon Jin; Park, Mi Youn; Jeong, Dong Jun; Cho, Moon Kyun
- Issue Date
- Aug-2010
- Publisher
- BIOMED CENTRAL LTD
- Citation
- JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, v.29, pp.1 - 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Volume
- 29
- Start Page
- 1
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174397
- DOI
- 10.1186/1756-9966-29-116
- ISSN
- 1756-9966
- Abstract
- Background: Src family kinases (SFKs) play an important role in cancer proliferation, survival, motility, invasiveness, metastasis, and angiogenesis. Among the SFKs, c-Src and c-Yes are particularly over-expressed or hyper-activated in many human epithelial cancers. However, only a few studies have attempted to define the expression and role of c-Src and c-Yes in cutaneous carcinomas. Objectives: To investigate the expression of c-Src and c-Yes in cutaneous carcinomas to include malignant melanoma (MM), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Methods: We examined 6 normal skin tissues and 18 malignant skin tumor tissues using western blotting for the expression of c-Src and c-Yes. In another set, 16 specimens of MM, 16 SCCs and 16 BCCs were analyzed for the expression of c-Src and c-Yes using immunohistochemical staining. Results: Western blotting showed that c-Src was expressed in all malignant skin tumors, but not in normal skin, while c-Yes was expressed in MM and SCC, but not in BCC and normal skin. Immunohistochemical staining results of c-Src and c-Yes in MM, SCC, and BCC mirrored those of the western blot analysis. Conclusions: c-Src, rather than c-Yes, plays a key role in the proliferation and progression of malignant skin cancers.
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