Matrix Metalloproteinase-1 Expression Can Be Upregulated through Mitogen-Activated Protein Kinase Pathway under the Influence of Human Epidermal Growth Factor Receptor 2 Synergized with Estrogen Receptor
- Authors
- Jung, Hae Hyun; Park, Yeon Hee; Jun, Hyun Jung; Kong, Jeehyun; Kim, Jeong Hoon; Kim, Jung A.; Yun, Jina; Sun, Jong Mu; Won, Young Woong; Lee, Soohyeon; Kim, Seung Tae; Ahn, Jin Seok; Im, Young-Hyuck
- Issue Date
- Jul-2010
- Publisher
- AMER ASSOC CANCER RESEARCH
- Citation
- MOLECULAR CANCER RESEARCH, v.8, no.7, pp.1037 - 1047
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR CANCER RESEARCH
- Volume
- 8
- Number
- 7
- Start Page
- 1037
- End Page
- 1047
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174523
- DOI
- 10.1158/1541-7786.MCR-09-0469
- ISSN
- 1541-7786
- Abstract
- In our previous work, Ets-1 upregulates human epidermal growth factor receptor 2 (HER2) induced matrix metalloproteinase 1 (MMP-1) expression. Based on the above knowledge and result, we hypothesized that estrogen receptor (ER) and its signaling pathway may affect MMP-1 expression under the influence of HER2. In addition, we investigated how the HER2 pathway cross-talk with the ER signaling pathway in genomic and nongenomic action of ER using reverse transcription-PCR, Western blot analysis, and ELISA assay. The results showed that ER-alpha expression increased MMP-1 expression under the presence of HER2. These upregulatory effects were mediated mainly by mitogen-activated protein kinase pathway and were reversed by downregulation of HER2 and/or ER. Activator protein DNA binding activity was involved in the MMP-1 expression. In summary, our results showed that ER can upregulate MMP-1 expression under the influence of HER2 in MCF-7 cells. In addition, this upregulatory effect was found to be mediated by mitogen-activated protein kinase pathway. MMP-1 might be an assigned target in interaction between ER and HER2.
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