Treatment Outcomes and Survival Based on Drug Resistance Patterns in Multidrug-resistant Tuberculosis
- Authors
- Kim, Doh Hyung; Kim, Hee Jin; Park, Seung-Kyu; Kong, Suck-Jun; Kim, Young Sam; Kim, Tae-Hyung; Kim, Eun Kyung; Lee, Ki Man; Lee, Sung-Soon; Park, Jae Seuk; Koh, Won-Jung; Lee, Chang-Hoon; Shim, Tae Sun
- Issue Date
- Jul-2010
- Publisher
- AMER THORACIC SOC
- Keywords
- tuberculosis; multidrug-resistant; survival rate; treatment outcome; drug susceptibility
- Citation
- AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, v.182, no.1, pp.113 - 119
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Volume
- 182
- Number
- 1
- Start Page
- 113
- End Page
- 119
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/174526
- DOI
- 10.1164/rccm.200911-1656OC
- ISSN
- 1073-449X
- Abstract
- Rationale: Few large-scale studies have investigated multidrug-resistant tuberculosis (MDR-TB) treatment outcomes relative to drug-resistance patterns. Objectives: To assess the impact of additional drug resistances on treatment outcomes and long-term survival in a large HIV-negative MDR-TB cohort. Methods: Treatment outcomes and long-term survival of patients with MDR-TB newly diagnosed or retreated in 2000 to 2002 were retrospectively analyzed based on drug-resistance patterns after 5-8 years of follow-up. Measurements and Main Results: Of 1,407 patients with MDR-TB, 75 (5.3%) had extensively drug-resistant TB (XDR-TB,) by the revised definition; 159 (11.3%) had ofloxacin-resistant pre-XDR-TB (pre-XDR-TB.); and 117 (8.3%) had second-line injectable drug (SLID)-resistant pre-XDR-TB (pre-XDR-TB(s)). Patients with XDR-TB, showed the lowest treatment success rate (29.3%) and the poorest long-term survival, and XDR-TB(re) was more strongly associated with long-term mortality than XDR-TB as originally defined (hazards ratio [HR], 3.15; 95% confidence interval [Cl], 2.06-4.83; P < 0.001 vs. HR, 2.15; 95% Cl, 1.49-3.09; P < 0.001). Patients with either form of pre-XDR-TB showed poorer cumulative survival than those with ofloxacin-susceptible/SLID-susceptible MDR-TB (P < 0.05 for each comparison). Although streptomycin susceptibility did not affect the treatment outcomes of patients with pre-XDR-TB, streptomycin-resistant pre-XDR-TB was more strongly associated with long-term mortality than ofloxacin-susceptible/SLID-susceptible MDR-TB (HR, 2.17; 95% Cl, 1.22-3.84; P < 0.008 for preXDR-TB.; and HR, 2.69; 95% Cl, 1.40-5.16; P= 0.003 for pre-XDR-TBs). Conclusions: The revised XDR-TB definition is appropriate for defining patients with MDR-TB with the poorest outcomes. Both pre-XDR-TB(o) and pre-XDR-TBs were independently associated with poor long-term survival in patients with MDR-TB. SM susceptibility was linked to better survival in patients with pre-XDR-TB.
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