Group-specific regional white matter abnormality revealed in diffusion tensor imaging of medial temporal lobe epilepsy without hippocampal sclerosisopen access
- Authors
- Shon, Young-Min; Kim, Yeong-In; Koo, Bang-Bon; Lee, Jong-Min; Kim, Hye J.; Kim, Woo J.; Ahn, Kook J.; Yang, Dong W.
- Issue Date
- Apr-2010
- Publisher
- WILEY
- Keywords
- Diffusion tensor imaging; Temporal lobe epilepsy; Nonlesional; Voxel-based
- Citation
- EPILEPSIA, v.51, no.4, pp.529 - 535
- Indexed
- SCIE
SCOPUS
- Journal Title
- EPILEPSIA
- Volume
- 51
- Number
- 4
- Start Page
- 529
- End Page
- 535
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175188
- DOI
- 10.1111/j.1528-1167.2009.02327.x
- ISSN
- 0013-9580
- Abstract
- P>Purpose: In comparison to temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (TLE-HS), TLE patients without HS (TLE-NH) have a similar clinical course but may result in worse surgical outcome. We investigated whether the clinical features related to the lack of HS in TLE patients (TLE-NH) can be explained by water diffusion abnormalities throughout diffusion tensor imaging (DTI) by voxel-based analysis. Methods: Nineteen patients with TLE-HS (left/right TLE 12:7), 18 patients with TLE-NH (left/right TLE 10:8), and 20 controls were included in the study. By statistical parametric mapping (SPM2), the diffusion properties specific to disease characteristics (TLE-HS vs. TLE-NH) were analyzed. Results: In TLE-HS, we found the areas of increased mean diffusivity (MD) in their ipsilateral temporal and extratemporal areas including the hippocampus, parahippocampal, and frontoparietal regions. Left TLE-HS showed a characteristic MD increase in the ipsilateral posterior cingulum, isthmus of corpus callosum, and contralateral occipital and temporal regions, which was not observed in right TLE-HS group. In left TLE-NH, two regions of increased MD were observed in the ipsilateral posterior fornix (within fusiform gyrus) and posterior cingulum. Right TLE-NH did not show any increased MD. Discussion: In left TLE-NH, we could find the water diffusion change along the posterior cingulum, which was quite different from the extensive abnormality from TLE-HS. In addition, there was a lesion-side-specific distribution (left predominant) of pathology in mesial TLE. This provides a possibility that TLE-NH is a heterogenous or entity different from TLE-HS.
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