Triad 1 induces apoptosis by p53 activation
- Authors
- Jung, Jin Hyuk; Lee, Sun-Mi; Bae, Seunghee; Lee, Su-Jae; Park, In-Chul; Jin, Young-Woo; Lee, Jae Ho; An, Sungkwan
- Issue Date
- Apr-2010
- Publisher
- WILEY
- Keywords
- Triad 1; Gfi-1; Apoptosis; p53; RING finger
- Citation
- FEBS LETTERS, v.584, no.8, pp.1565 - 1570
- Indexed
- SCIE
SCOPUS
- Journal Title
- FEBS LETTERS
- Volume
- 584
- Number
- 8
- Start Page
- 1565
- End Page
- 1570
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175208
- DOI
- 10.1016/j.febslet.2010.03.011
- ISSN
- 0014-5793
- Abstract
- Triad 1 (2 RING [ really interesting new gene] fingers and DRIL [double RING finger linked] 1) is an E3 ligase that induces apoptosis and clonogenic inhibition in myeloid cells through Gfi-1 stabilization. Here we demonstrate that Triad 1 induces apoptosis in several cancer cell lines including MCF7, A549, U2OS, and HCT 116 p53(+/+) cells via its RING ligase activity. Interestingly, in these cancer cells, Triad 1-induced apoptosis is not mediated by Gfi-1 stabilization but is instead p53-dependent. Moreover, Triad 1 promotes transactivation of p53. These results suggest that Triad 1 can induce apoptosis through its ligase activity via p53 activation.
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