The Development of Genipin-Crosslinked Poly(caprolactone) (PCL)/Gelatin Nanofibers for Tissue Engineering Applications
- Authors
- Kim, Min Sup; Jun, Indong; Shin, Young Min; Jang, Wonhee; Kim, Sun I.; Shin, Heungsoo
- Issue Date
- Jan-2010
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- electrospinning; gelatin; polycaprolactone; skeletal muscles; tissue engineering
- Citation
- MACROMOLECULAR BIOSCIENCE, v.10, no.1, pp.91 - 100
- Indexed
- SCIE
SCOPUS
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 10
- Number
- 1
- Start Page
- 91
- End Page
- 100
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/175600
- DOI
- 10.1002/mabi.200900168
- ISSN
- 1616-5187
- Abstract
- Composite nano-fibers of poly(caprolactone) (PCL) and gelatin crosslinked with genipin are prepared. The contact angles and mechanical properties of crosslinked PCL-gelatin nanofibers decrease as the gelatin content increases. The proliferation of myoblasts is higher in the crosslinked PCL-gelatin nanofibers than in the PCL nanofibers, and the formation of myotubes is only observed on the crosslinked PCL-gelatin nanofibers. The expression level of myogenin, myosin heavy chain, and troponin T genes is increased as the gelatin content is increased. The results suggest that PCL-gelatin nanofibers crosslinked with genipin can be used as a substrate to modulate proliferation and differentiation of myoblasts, presenting potential applications in muscle tissue engineering.
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