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Identification of TRPM7 channels in human intestinal interstitial cells of Cajalopen access
- Authors
- Kim, Byung Joo; Park, Kyu Joo; Kim, Hyung Woo; Choi, Seok; Jun, Jae Yeoul; Chang, In Youb; Jeon, Ju-Hong; So, Insuk; Kim, Seon Jeong
- Issue Date
- Dec-2009
- Publisher
- BAISHIDENG PUBLISHING GROUP INC
- Keywords
- Electrophysiology; Interstitial cells of Cajal; TRPM cation channels; Transient receptor potential melastatin-type 7 protein; Human; Gastrointestinal tract
- Citation
- WORLD JOURNAL OF GASTROENTEROLOGY, v.15, no.46, pp.5799 - 5804
- Indexed
- SCIE
SCOPUS
- Journal Title
- WORLD JOURNAL OF GASTROENTEROLOGY
- Volume
- 15
- Number
- 46
- Start Page
- 5799
- End Page
- 5804
- ISSN
- 1007-9327
- Abstract
- AIM: To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 (TRPM7) in the human gastrointestinal (GI) tract. METHODS: Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajal (ICCs). RESULTS: The human GI tract generated slow electrical waves and had ICCs which functioned as pacemaker cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB (2-aminoethoxydiphenyl borate) and La3+, TRPM7 channel blockers, inhibited the slow waves. Also, TRPM7 channels were expressed in ICCs in human tissue. CONCLUSION: These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the generation of the slow waves.
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Related Researcher
- Kim, Seon Jeong
- COLLEGE OF ENGINEERING (서울 바이오메디컬공학전공)