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Autophagy genes mediate the effect of calcineurin on life span in C. elegans
- Authors
- Dwivedi, Meenakshi; Song, Hyun-Ok; Ahnn, Joohong
- Issue Date
- Jul-2009
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- calcineurin; autophagy; life span; beclin 1; Atg-7; GFP::LGG-1 expression
- Citation
- AUTOPHAGY, v.5, no.5, pp.604 - 607
- Indexed
- SCIE
SCOPUS
- Journal Title
- AUTOPHAGY
- Volume
- 5
- Number
- 5
- Start Page
- 604
- End Page
- 607
- ISSN
- 1554-8627
- Abstract
- Calcineurin (CaN) is a serine/threonine phosphatase, activated by Ca2+/calmodulin (Ca2+/CaM). CaN is known to regulate various cellular responses in different organisms. A recent study showed an extended life span in the calcineurin mutants of C elegans. In this study, we report that calcineurin defective strains exhibit enhanced autophagy. In addition, we found two essential autophagy genes (bec-1 and atg-7) are required for the life-span extension in calcineurin null mutants [cnb-1(jh103)]. Thus, for the first time we suggest that autophagy genes are required for the life-span regulation in calcineurin defective C. elegans strains.
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Related Researcher
- Ahnn, Joo Hong
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF LIFE SCIENCE)