pH-Dependent Structures of an i-Motif DNA in Solution
- Authors
- Jin, Kyeong Sik; Shin, Su Ryon; Ahn, Byungcheol; Rho, Yecheol; Kim, Seon Jeong; Ree, Moonhor
- Issue Date
- Feb-2009
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF PHYSICAL CHEMISTRY B, v.113, no.7, pp.1852 - 1856
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF PHYSICAL CHEMISTRY B
- Volume
- 113
- Number
- 7
- Start Page
- 1852
- End Page
- 1856
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177333
- DOI
- 10.1021/jp808186z
- ISSN
- 1520-6106
- Abstract
- We have investigated for the first time the structure of i-motif DNA in solution at various pH conditions by using synchrotron small-angle X-ray scattering technique. To facilitate direct structural. comparison between solution structures of i-motif DNA at various pH values, we created atomic coordinates of i-motif DNA from a fully folded to unfolded atomic model. Under mild acidic conditions, the conformations for i-motif DNA appeared to be similar to that of the partially unfolded i-motif atomic model in overall shape, rather than the fully folded i-motif atomic model. Collectively, our observations indicate that i-motif DNA molecule is structurally dynamic over a wide pH range, adopting multiple conformations ranging from the folded i-motif structure to a random coil conformation. As the i-motif structure has been used as an important component in nanomachines, we can therefore believe that the structural evidence presented herein will promote the development of future DNA-based molecular-actuator devices.
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