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Improvement of Differentiation and Mineralization of Pre-Osteoblasts on Composite Nanofibers of Poly(lactic acid) and Nanosized Bovine Bone Powder
- Issue Date
- Dec-2008
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- biodegradable; composites; fibers; microstructure; mineral
- Citation
- MACROMOLECULAR BIOSCIENCE, v.8, no.12, pp.1098 - 1107
- Indexed
- SCIE
SCOPUS
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 8
- Number
- 12
- Start Page
- 1098
- End Page
- 1107
- ISSN
- 1616-5187
- Abstract
- The effect of NBM incorporation in PLA nanofibers on their mechanical properties and the differentiation and mineralization of osteoblasts was studied. At 20% NBM, the Young's modulus of the nanofibers was 37.78 +/- 4.23, significantly larger than that of pure PLA nanofibers. MCM-E1 pre-osteoblasts attached to both types of nanofibers and developed full osteogenic phenotypes. A profound effect of NBM on the mineralization of MCM-E1 pre-osteoblasts was confirmed, suggesting that NBM/PLA composite nanofibers exhibit properties similar to those of the native collagen-rich mineralized bone matrix, and could therefore serve as a temporary substrate for facilitating the differentiation and mineralization of bone-forming cells.
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Collections - 서울 공과대학 > 서울 생명공학과 > 1. Journal Articles
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Related Researcher
- Shin, Heung Soo
- COLLEGE OF ENGINEERING (DEPARTMENT OF BIOENGINEERING)