Berberine Diminishes the Side Population and ABCG2 Transporter Expression in MCF-7 Breast Cancer Cells
- Authors
- Kim, Jong Bin; Ko, Eunyoung; Han, Wonshik; Shin, Incheol; Park, Seo Young; Noh, Dong-Young
- Issue Date
- Nov-2008
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- berberine; breast cancer; cancer stem cells; side population; ABCG2
- Citation
- PLANTA MEDICA, v.74, no.14, pp.1693 - 1700
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLANTA MEDICA
- Volume
- 74
- Number
- 14
- Start Page
- 1693
- End Page
- 1700
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/177700
- DOI
- 10.1055/s-0028-1088313
- ISSN
- 0032-0943
- Abstract
- The plant alkaloid berberine has many biological activities including the ability to induce cell cycle arrest and apoptosis, making it a potentially useful agent for targeting cancer cells. We have analyzed the effects of berberine oil MCF-7 breast cancer cells. Berberine was added to MCF-7 cells in Culture, and proliferation, side population (SP) cells and expression of ABCG2 were examined. Berberine caused a close-dependent reduction in Proliferation. Hoechst 33342 dye staining and FACS analysis revealed that berberine treatment caused a decrease in SP cells relative to untreated controls. In addition, berberine treatment was associated with a decrease in expression of ABCG2 relative to untreated controls. These results indicate that the growth inhibitory effects of berberine treatment on MCF-7 cells may be partly via effects oil SP and ABCG2 expression. Further work is warranted to explore whether berberine may be a novel therapeutic drug useful for targeting breast cancer stem cells.
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