TNF-alpha polymorphisms in Korean adult-onset Still's disease patients
- Authors
- Sung, Yoon-Kyoung; Seong, Sang-Seokg; Woo, Jin-Hyun; Lee, Myung-Ho; Chung, Won-Tae; Choe, Jeong-Yoon; Yoo, Dae-Hyun
- Issue Date
- Jul-2008
- Publisher
- WILEY
- Keywords
- adult-onset Still' s disease; Korean; polymorphism; TNF-alpha
- Citation
- INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v.11, no.2, pp.155 - 162
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
- Volume
- 11
- Number
- 2
- Start Page
- 155
- End Page
- 162
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178162
- DOI
- 10.1111/j.1756-185X.2008.00351.x
- ISSN
- 1756-1841
- Abstract
- Aim: To investigate the role of TNF-alpha promoter polymorphisms in the pathogenesis of Korean adult-onset Still's disease (AOSD) patients. Methods: DNA was isolated from blood samples collected from 58 patients with AOSD meeting Yamaguchi's criteria and 105 healthy controls. TNF-alpha promoter polymorphisms at positions -1013, -863, -857, -308 were analysed by polymerase chain reaction-restriction fragment length polymorphism method. Genotype, allele, and estimated haplotype frequencies were compared between the AOSD group and controls. Results: The genotype, allele distributions, and estimated haplotype frequencies of the TNF-alpha polymorphism between AOSD patients and controls were not significantly different. In addition, TNF-alpha polymorphisms did not appear to have an effect on the disease course of the Korean AOSD patients. Conclusion: Genetic polymorphisms of TNF-alpha do not play a significant role in the development or in their course of Korean AOSD patients.
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