Development of electroactive and elastic nanofibers that contain polyaniline and poly(L-lactide-co-epsilon-caprolactone) for the control of cell adhesion
- Authors
- Jeong, Sung In; Jun, In Dong; Choi, Moon Jae; Nho, Young Chang; Lee, Young Moo; Shin, Heungsoo
- Issue Date
- Jul-2008
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- conducting polymers; electrospinning; nanofibers; polyaniline; poly(L-lactide-co-epsilon-caprolactone)
- Citation
- MACROMOLECULAR BIOSCIENCE, v.8, no.7, pp.627 - 637
- Indexed
- SCIE
SCOPUS
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 8
- Number
- 7
- Start Page
- 627
- End Page
- 637
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/178202
- DOI
- 10.1002/mabi.200800005
- ISSN
- 1616-5187
- Abstract
- In this work, electrically conductive polyaniline (PAni) doped with camphorsulfonic acid (CPSA) is blended with poly(L-lactide-co-epsilon-caprolactone) (PLCL), and then electrospun to prepare uniform nanofibers. The CPSA-PAni/PLCL nanofibers show a smooth fiber structure without coarse lumps or beads and consistent fiber diameters (which range from 100 to 700 nm) even with an increase in the amount of CPSA-PAni (from 0 to 30 wt.-%). However, the elongation at break decreases from 391.54 +/- 9.20% to 207.85 +/- 6.74% when 30% of CPSA-PAni is incorporated. Analysis of the surface of the nanofibers demonstrates the presence of homogeneously blended CPSA-PAni. Most importantly, a four-point probe analysis reveals that electrical properties are maintained in the nanofibers where the conductivity is significantly increased from 0.0015 to 0.0138 S . cm(-1) when the nanofibers are prepared with 30% CPSA-PAni. The cell adhesion tests using human dermal fibroblasts, NIH-3T3 fibroblasts, and C2C12 myoblasts demonstrate significantly higher adhesion on the CPSA-PAni/PLCL nanofibers than pure PLCL nanofibers. In addition, the growth of NIH-3T3 fibroblasts is enhanced under the stimulation of various direct current flows. The CPSA-PAni/PLCL nanofibers with electrically conductive properties may potentially be used as a platform substrate to study the effect of electrical signals on cell activities and to direct desirable cell function for tissue engineering applications.
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