Abnormal cortical neural synchrony during working memory in schizophreniaopen access
- Authors
- Kang, Seung Suk; MacDonald, Angus W., III; Chafee, Matthew V.; Im, Chang-Hwan; Bernat, Edward M.; Davenport, Nicholas D.; Sponheim, Scott R.
- Issue Date
- Jan-2018
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Schizophrenia; Working memory; Neural oscillation; Cortical source analysis; Magnetoencephalography (MEG)
- Citation
- CLINICAL NEUROPHYSIOLOGY, v.129, no.1, pp.210 - 221
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL NEUROPHYSIOLOGY
- Volume
- 129
- Number
- 1
- Start Page
- 210
- End Page
- 221
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/17863
- DOI
- 10.1016/j.clinph.2017.10.024
- ISSN
- 1388-2457
- Abstract
- Objective: To better understand the origins of working memory (WM) impairment in schizophrenia we investigated cortical oscillatory activity in people with schizophrenia (PSZ) while they performed a WM task requiring encoding, maintenance, and retrieval/manipulation processes of spatial information. Methods: We examined time-frequency synchronous energy of cortical source signals that were derived from magnetoencephalography (MEG) localized to cortical regions using WM-related hemodynamic responses and individualized structural head-models. Results: Compared to thirteen healthy controls (HC), twelve PSZ showed performance deficits regardless of WM-load or duration. During encoding, PSZ had early theta and delta event-related synchrony (ERS) deficits in prefrontal and visual cortices which worsened with greater memory load and predicted WM performance. During prolonged maintenance of material, PSZ showed deficient beta event-related desynchrony (ERD) in dorsolateral prefrontal, posterior parietal, and visual cortices. In retrieval, PSZ showed reduced delta/theta ERS in the anterior prefrontal and ventral visual cortices and diminished gamma ERS in the premotor and posterior parietal cortices. Conclusions: Although beta/gamma cortical neural oscillatory deficits for maintenance/retrieval are evident during WM, the abnormal prefrontal theta-frequency ERS for encoding is most predictive of poor WM in schizophrenia. Significance: Time-frequency-spatial analysis identified process-and frequency-specific neural synchrony abnormalities underlying WM deficits in schizophrenia. (C) 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
- Files in This Item
-
Go to Link
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/17863)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.