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Synthesis of novel phytosphingosine derivatives and their preliminary biological evaluation for enhancing radiation therapy
- Authors
- Moon, Byung Seok; Park, Moon-Taek; Park, Jeong Hoon; Kim, Sang Wook; Lee, Kyo Chul; An, Gwang Il; Yang, Seung Dae; Chi, Dae Yoon; Cheon, Gi Jeong; Lee, Su-Jae
- Issue Date
- Dec-2007
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Phytoceramide; Phytosphingosine; Radiosensitizer; Sphingolipids
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.17, no.23, pp.6643 - 6646
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 17
- Number
- 23
- Start Page
- 6643
- End Page
- 6646
- ISSN
- 0960-894X
- Abstract
- Eight D-ribo-phytosphingosine derivatives were synthesized from D-ribo-phytosphingosine and diverse acyl chlorides with N,N-diisopropylethylamine in tetrahydrofuran for 1 h at room temperature. Effect of these compounds on IR-induced cell death was evaluated on blood cancer cells (Jurkat). Among these, 3d showed the highest enhancement of radiosensitizing effect.
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