난소의 경계성 및 악성 표면상피종양에서 c-erbB-2, EGFR, p53 발현 및 Ki-67 지수에 관한 연구The expression of c-erbB-2, EGFP, p53 and Ki-67 in ovarian borderline tumors and carcinomas of the ovary
- Other Titles
- The expression of c-erbB-2, EGFP, p53 and Ki-67 in ovarian borderline tumors and carcinomas of the ovary
- Authors
- 민경환; 박문향
- Issue Date
- Oct-2007
- Publisher
- KOREAN SOCIETY PATHOLOGISTS
- Keywords
- ovarian neoplasms; receptor; erbB-2; epidermal growth factor; p53 antigen; Ki-67 antigen
- Citation
- KOREAN JOURNAL OF PATHOLOGY, v.41, no.5, pp.296 - 306
- Indexed
- SCIE
- Journal Title
- KOREAN JOURNAL OF PATHOLOGY
- Volume
- 41
- Number
- 5
- Start Page
- 296
- End Page
- 306
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/179494
- ISSN
- 1738-1843
- Abstract
- Background : An ovarian surface epithelial tumor is a heterogenous disease, and various biological and molecular factors are important for its development and progression. Several findings support EGFR or c-erbB-2 as adverse prognostic indicators for an ovarian carcinoma. Methods : We reviewed the histological and clinical findings of 52 carcinomas (17 endometrioid, 16 serous, 13 mucinous and 6 clear cell tumors), and 26 borderline (10 serous and 16 mucinous) tumors. Expression of c-erbB-2, EGFR, p53, and Ki-67 was evaluated on paraffin-embedded tissue from a primary ovarian tumor by immunohistochemical methods. Results: Expression of c-erbB-2 was found in 7.6% of tumors and expression of EGFR was found in 9.6% of tumors by immunohistochemical analysis. No significance was found between cerbB-2 and EGFR expression as indicators of a poor prognosis. The expression of p53 and Ki-67 (>50%) correlated with the grade and type of tumor in the ovarian cancers. p53 and Ki-67 overexpression (>50%) was absent in the borderline ovarian tumors, whereas ovarian carcinomas showed expression of both p53 and Ki-67. Conclusion : Expression of c-erbB2, EGFR, p53, and Ki-67 as determined by immunohistochemical analysis did not correlate with prognostic significance. However, p53 and Ki-67 expression may be used as markers to predict aggressive behavior, and to differentiate between malignant and borderline epithelial ovarian tumors. Further large-scale studies are required to clarify the significance of c-erbB-2 and EGFR expression in ovarian tumors.
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