IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette emphysema and inflammationopen access
- Authors
- Kang, Min-Jong; Homer, Robert J.; Gallo, Amy; Lee, Chun Geun; Crothers, Kristina A.; Cho, Soo Jung; Rochester, Carolyn; Cain, Hilary; Chupp, Geoffrey; Yoon, Ho Joo; Elias, Jack A.
- Issue Date
- Feb-2007
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Citation
- JOURNAL OF IMMUNOLOGY, v.178, no.3, pp.1948 - 1959
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Volume
- 178
- Number
- 3
- Start Page
- 1948
- End Page
- 1959
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180489
- DOI
- 10.4049/jimmunol.178.3.1948
- ISSN
- 0022-1767
- Abstract
- Th1 inflammation and remodeling characterized by local tissue destruction coexist in pulmonary emphysema and other diseases. To test the hypothesis that IL-18 plays an important role in these responses, we characterized the regulation of IL-18 in lungs from cigarette smoke (CS) and room air-exposed mice and characterized the effects of CS in wild-type mice and mice with null mutations of IL-18R alpha (IL-18R alpha(-/-)). CS was a potent stimulator and activator of IL-18 and caspases 1 and 11. In addition, although CS caused inflammation and emphysema in wild-type mice, both of these responses were significantly decreased in IL-18Ra-/- animals. CS also induced epithelial apoptosis, activated effector caspases and stimulated proteases and chemokines via IL-18R alpha-dependent pathways. Importantly, the levels of IL-18 and its targets, cathepsins S and B, were increased in pulmonary macrophages from smokers and patients with chronic obstructive lung disease. Elevated levels of circulating IL-18 were also seen in patients with chronic obstructive lung disease. These studies demonstrate that IL-18 and the IL-18 pathway are activated in CS-exposed mice and man. They also demonstrate, in a murine modeling system, that IL-18R signaling plays a critical role in the pathogenesis of CS-induced inflammation and emphysema.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180489)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.