Cyclooxygenase-2 polymorphisms and risk of systemic lupus erythematosus in Koreans
- Authors
- Her, Min-Young; El-Sohemy, Ahmed; Cornelis, Marilyn C.; Kim, Tae-Hwan; Bae, Sang-Cheol
- Issue Date
- Nov-2006
- Publisher
- SPRINGER
- Keywords
- cyclooxygenase-2; systemic lupus erythematosus; polymorphism
- Citation
- RHEUMATOLOGY INTERNATIONAL, v.27, no.1, pp.1 - 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- RHEUMATOLOGY INTERNATIONAL
- Volume
- 27
- Number
- 1
- Start Page
- 1
- End Page
- 5
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/180769
- DOI
- 10.1007/s00296-006-0162-z
- ISSN
- 0172-8172
- Abstract
- Cyclooxygenase-2 (COX-2) is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. Upregulation of COX-2 in human lupus T cells resists anergy and apotosis. We investigated the COX-2 gene for functional variants that may influence susceptibility, clinical outcomes and severity of systemic lupus erythematosus (SLE) in a Korean population. The study included 345 patients with SLE and 400 unrelated healthy controls. Genotyping for the -765G -> C polymorphism of COX-2 was performed by PCR - RFLP analysis. No difference in the distribution of the genotype frequencies between patients and controls was found. COX-2 genotypes were not associated with clinical features except hematologic abnormalities and anti-RNP antibody. We did not detect any association between COX-2 genotype and disease severity in SLE patients. These results suggest that the -765G -> C polymorphism of COX-2 does not play a significant role in the development of SLE in a Korean population. A possible protective effect of the low activity C allele against the production of anti-RNP antibodies merits further investigation.
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