Interfering antiviral immunity: application, subversion, hope?open access
- Authors
- Manjunath, N.; Kumar, Priti; Lee, Sang Kyung; Shankar, Premlata
- Issue Date
- Jul-2006
- Publisher
- ELSEVIER SCI LTD
- Citation
- TRENDS IN IMMUNOLOGY, v.27, no.7, pp.328 - 335
- Indexed
- SCIE
SCOPUS
- Journal Title
- TRENDS IN IMMUNOLOGY
- Volume
- 27
- Number
- 7
- Start Page
- 328
- End Page
- 335
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181222
- DOI
- 10.1016/j.it.2006.05.006
- ISSN
- 1471-4906
- Abstract
- RNA interference (RNAi), initially recognized as a natural antiviral mechanism in plants, has rapidly emerged as an invaluable tool to suppress gene expression in a sequence-specific manner in all organisms, including mammals. Its potential to inhibit the replication of a variety of viruses has been demonstrated in vitro and in vivo in mouse and monkey models. These results have generated profound interest in the use of this technology as a potential treatment strategy for viral infections for which vaccines and drugs are unavailable or inadequate. In this review, we discuss the progress made within the past 2-3 years towards harnessing the potential of RNAi for clinical application in viral infections and the hurdles that have yet to be overcome.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 공과대학 > 서울 생명공학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181222)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.