Cyclooxygenase-2 genotype and rheumatoid arthritis
- Authors
- Lee, Kyu Hoon; Kim, Hee-Sang; El-Sohemy, Ahmed; Cornelis, Marilyn C.; Uhm, Wan-Sik; Bae, Sang-Cheol
- Issue Date
- Jul-2006
- Publisher
- J RHEUMATOL PUBL CO
- Keywords
- polymorphism; cyclooxygenase-2; shared epitope; Korea; rheumatoid arthritis
- Citation
- JOURNAL OF RHEUMATOLOGY, v.33, no.7, pp.1231 - 1234
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF RHEUMATOLOGY
- Volume
- 33
- Number
- 7
- Start Page
- 1231
- End Page
- 1234
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/181232
- ISSN
- 0315-162X
- Abstract
- Objective. To determine the association between cyclooxygenase-2 (COX-2) genotypes and risk and severity of rheumatoid arthritis (RA) in a Korean population. Methods. A total of 258 Korean patients with RA and 400 control subjects were recruited from Hanyang University Hospital. Subjects were genotyped for the -765G/C polymorphism of the COX-2 gene by RFLP-PCR analysis. Odds ratios (OR) and 95% confidence intervals (0) were calculated to estimate risk. Severity of RA was assessed by anatomical stage according to Steinbrocker. et al. Results. No association was observed between COX-2 genotype and risk or severity of RA. However, among those without the shared epitope (SE), carriers of the low activity C allele had a lower risk of RA and less severe form of RA than subjects with the GIG genotype. The OR (95% Q was 0.36 (0.14-0.95) for risk of RA and 0.04 (0.01-0.41) for seventy. Conclusion. These results suggest that COX-2 genotyping might be useful in predicting the risk and severity of RA in individuals without the SE.
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