Adipocytolytic Polymer Nanoparticles for Localized Fat Reduction
- Authors
- Han, Young Kyoung; Jeong, Eun Ju; Seo, Yerang; Lee, In Young; Choi, Suim; Lee, Hyewon; Kim, Choonggu; Rhim, Taiyoun; Lee, Kuen Yong
- Issue Date
- Jan-2023
- Publisher
- AMER CHEMICAL SOC
- Keywords
- adipocytolysis; local injection; fat reduction; polymer nanoparticle; carbon dioxide gas
- Citation
- ACS NANO, v.17, no.1, pp.70 - 83
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS NANO
- Volume
- 17
- Number
- 1
- Start Page
- 70
- End Page
- 83
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/182222
- DOI
- 10.1021/acsnano.2c04108
- ISSN
- 1936-0851
- Abstract
- The demand for body fat reduction is increasing. However, conventional lipolytic approaches fail to control adipose tissue reduction and cause severe side effects in adjacent nonadipose tissues. A strategy to specifically reduce subcutaneous fat using adipocytolytic polymer nanoparticles in a minimally invasive manner is reported here. The polymer nanoparticles are designed to generate carbon dioxide gas when selectively absorbed by adipocytes. The carbon dioxide gas generated within late endosomes/lysosomes induces adipocytolysis, thereby reducing the number of cells. Localized injection of the adipocytolytic nanoparticles substantially reduces subcutaneous fat in a high-fat diet-induced obese mouse model, without significant changes in hematological or serum biochemical parameters. The adipocytolytic efficacy of the nanoparticles is also evaluated in a porcine model. This strategy addresses the need to develop safe and effective adipocytolytic agents using functional polymer nanoparticles.
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