Comparison of Three Cardiovascular Risk Scores among HIV-Infected Patients in Korea: The Korea HIV/AIDS Cohort Studyopen access
- Authors
- Bae, Ji Yun; Kim, Soo Min; Choi, Yunsu; Choi, Jun Yong; Kim, Sang Il; Kim, Shin-Woo; Park, Bo Young; Choi, Bo Youl; Choi, Hee Jung
- Issue Date
- Sep-2022
- Publisher
- Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS
- Keywords
- HIV; Korea; Cardiovascular diseases; Coronary disease
- Citation
- Infection and Chemotherapy, v.54, no.3, pp.409 - 418
- Indexed
- SCOPUS
KCI
- Journal Title
- Infection and Chemotherapy
- Volume
- 54
- Number
- 3
- Start Page
- 409
- End Page
- 418
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/185818
- DOI
- 10.3947/ic.2022.0048
- ISSN
- 2093-2340
- Abstract
- Background
We investigated cardiovascular disease (CVD), risk factors for CVD, and applicability of the three known CVD risk equations in the Korean human immunodeficiency virus/ Acquired Immune Deficiency Syndrome (HIV/AIDS) cohort.
Materials and Methods
The study parcitipants were HIV-infected patients in a Korean HIV/AIDS cohort enrolled from 19 hospitals between 2006 and 2017. Data collected at entry to the cohort were analyzed. The 5-year CVD risk in each participant was calculated using three CVD risk equations: reduced CVD prediction model of HIV-specific data collection on adverse effects of anti-HIV drugs (R-DAD), Framingham general CVD risk score (FRS), and Korean Coronary Heart Disease Risk Score (KRS).
Results
CVD events were observed in 11 of 586 HIV-infected patients during a 5-year (median) follow-up period. The incidence of CVD was 4.11 per 1,000 person-years. Older age (64 vs. 41 years, P = 0.005) and diabetes mellitus (45.5% vs. 6.4%, P <0.001) were more frequent in patients with CVD. Using R-DAD, FRS, and KRS, 1.9%, 2.4%, and 0.7% of patients, respectively, were considered to have a very high risk (≥10%) of 5-year CVD. The discriminatory capacities of the three prediction models were good, with c-statistic values of 0.829 (P <0.001) for R-DAD, 0.824 (P <0.001) for FRS, and 0.850 (P = 0.001) for KRS.
Conclusion
The FRS, R-DAD, and KRS performed well in the Korean HIV/AIDS cohort. A larger cohort and a longer period of follow-up may be necessary to demonstrate the risk factors and develop an independent CVD risk prediction model specific to Korean patients with HIV.
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