연잎 및 도라지 혼합추출물의 3T3-L1 세포 내 지방축적 억제효과

Abstract

The continuous increase in obesity necessitates innovative preventive measures. Plant extracts from Diospyros kaki L. (DE), Nelumbo nucifera L. (NE), Rosa canina (RE), Chrysanthemum morifolium (CE), and Platycodon grandiflorus (PE) have been traditionally consumed for medicinal purposes in Asia and Europe. In this study, we evaluated the antiobesity effects of plant extracts. Fat accumulation was inhibited by PE, DE, and NE in a dose-dependent manner. NE was further mixed at ratios of 1:1-1:5 with PE, and a mixture of 300 μg/mL showed no less reduction in cellular fat than 600 μg/mL of the mixture. Representative enzymes related to lipogenesis and thermogenesis were evaluated. FAS was reduced, whereas uncoupling-protein 1 (UCP1) was enhanced in adipocytes up to 300 μg/mL of a mixture. In conclusion, the combined extract of NE and PE (1:5) is a potent nutraceutical with anti-obesity effects.