Micro-ultrasonic Assessment of Early Stage Clot Formation and Whole Blood Coagulation Using an All-Optical Ultrasound Transducer and Adaptive Signal Processing Algorithm
- Authors
- Biswas, Deblina; Heo, Jeongmin; Sang, Pilgyu; Dey, Prasanta; Han, Kayoung; Ko, Jong Hwan; Won, Sang Min; Son, Donghee; Suh, Minah; Kim, Hyung Sik; Ok, Jong G.; Park, Hui Joon; Baac, Hyoung Won
- Issue Date
- Sep-2022
- Publisher
- AMER CHEMICAL SOC
- Keywords
- blood coagulation; all-optical ultrasound; laser-generated focused ultrasound; empirical mode decomposition; viscoelasticity
- Citation
- ACS SENSORS, v.7, no.10, pp.2940 - 2950
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS SENSORS
- Volume
- 7
- Number
- 10
- Start Page
- 2940
- End Page
- 2950
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/186117
- DOI
- 10.1021/acssensors.2c00875
- ISSN
- 2379-3694
- Abstract
- Abnormal formation of solid thrombus inside a blood vessel can cause thrombotic morbidity and mortality. This necessitates early stage diagnosis, which requires quantitative assessment with a small volume, for effective therapy with low risk to unwanted development of various diseases. We propose a micro-ultrasonic diagnosis using an all-optical ultrasound-based spectral sensing (AOUSS) technique for sensitive and quantitati. characterization of early stage and whole blood coagulation. The AOUSS technique detects and analyzes minute viscoelastic variations of blood at a micro-ultrasonic spot (<100 mu m) defined by laser-generated focused ultrasound (LGFU). This utilizes (1) a uniquely designed optical transducer configuration for frequency-spectral matching and wideband operation (6 dB widths: 7-32 MHz and d.c. similar to 46 MHz, respectively) and (2) an empirical mode decomposition (EMD)-based signal process particularly adapted to nonstationary LGFU signals backscattered from the spot. An EMD-derived spectral analysis enables one to assess viscoelastic variations during the initiation of fibrin formation, which occurs at a very early stage of blood coagulation (1 min) with high sensitivity (frequency transition per storage modulus increment = 8.81 MHz/MPa). Our results exhibit strong agreement with those obtained by conventional rheometry (Pearson's R > 0.95), which are also confirmed by optical microscopy. The micro-ultrasonic and high-sensitivity detection of AOUSS poses a potential clinical significance, serving as a screening modality to diagnose early stage clot formation (e.g., as an indicator for hypercoagul ation of blood) and stages of blood-to-clot transition to check a potential risk for development into thrombotic diseases.
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