Multi-Sensory Integration Impairment in Patients with Minimal Hepatic Encephalopathyopen access
- Authors
- Seo, Kyoungwon; Jun, Dae Won; Kim, Jae-kwan; Ryu, Hokyoung
- Issue Date
- Nov-2017
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.7, no.1, pp.1 - 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 7
- Number
- 1
- Start Page
- 1
- End Page
- 7
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/18677
- DOI
- 10.1038/s41598-017-15113-1
- ISSN
- 2045-2322
- Abstract
- Paper-and-pencil-based psychometric tests are the gold standard for diagnosis of cognitive dysfunction in liver disease. However, they take time, can be affected by demographic factors, and lack ecological validity. This study explored multi-sensory integration ability to discriminate cognitive dysfunction in cirrhosis. Thirty-two healthy controls and 30 cirrhotic patients were recruited. The sensory integration test presents stimuli from two different modalities (e.g., image/sound) with a short time lag, and subjects judge which stimuli appeared first. Repetitive tests reveal the sensory integration capability. Performance in the sensory integration test, psychometric tests, and functional near-infrared spectroscopy for patients was compared to controls. Sensory integration capability, the perceptual threshold to discriminate the time gap between an image and sound stimulus, was significantly impaired in cirrhotic patients with minimal hepatic encephalopathy (MHE) compared to controls (p < 0.01) and non-MHE patients (p < 0.01). Sensory integration test showed good correlation with psychometric tests (NCT-A, r = 0.383, p = 0.002; NCT-B, r = 0.450, p < 0.01; DST-F, r = -0.322, p = 0.011; DST-B, r = -0.384, p = 0.002; ACPT, r = -0.467, p < 0.01). Psychometric tests were dependent on age and education level, while the sensory integration test was not affected. The sensory integration test, where a cut-off value for the perceptual threshold was 133.3ms, recognized MHE patients at 90% sensitivity and 86.5% specificity.
- Files in This Item
-
- Appears in
Collections - 서울 기술경영전문대학원 > 서울 기술경영학과 > 1. Journal Articles
- 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/18677)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.