Role of Shear Wave Elastography in Evaluating the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis Bopen access
- Authors
- Jeong, Jae Yoon; Sohn, Joo Hyun; Sohn, Won; Park, Chan Hyuk; Kim, Tae Yeob; Jun, Dae Won; Kim, Yongsoo; Jeong, Woo Kyoung
- Issue Date
- Nov-2017
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- Elastography; shear wave; Liver stiffness; Hepatitis B; chronic; Carcinoma; hepatocellular
- Citation
- GUT AND LIVER, v.11, no.6, pp.852 - 859
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- GUT AND LIVER
- Volume
- 11
- Number
- 6
- Start Page
- 852
- End Page
- 859
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/18687
- DOI
- 10.5009/gnl16521
- ISSN
- 1976-2283
- Abstract
- Background/Aims: To investigate the use of measurements of liver stiffness (LS) by two-dimensional real-time shear wave elastography (SWE) for predicting the development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Methods: We retrospectively collected data on 291 enrolled patients with CHB whose LS had been measured using SWE.
Results: The mean age of the patients was 46.8 years; males predominated (67%), and 40 of the patients (14%) had clinical cirrhosis. Among the patients, 165 (56.7%) received antiviral treatment. The median LS value was 7.4 kPa, and the median follow-up period was 35.8 months (range, 3.0 to 52.8 months). During follow-up, HCC developed in 13 patients (4.5%), and the cumulative incidence rates of HCC at 1, 2, and 4 years were 1.1%, 3.6%, and 8.4%, respectively. Based on a multivariate analysis, older age (>= 50 years) and higher LS value (>= 10 kPa) were independently associated with the risk of developing HCC (hazard ratio [HR], 4.53, p=0.023; and HR, 4.08, p=0.022). The cumulative incidence rate of HCC was significantly higher in patients with higher LS values (>= 10 kPa) than in those with lower LS values (< 10 kPa) (p=0.001). Conclusions: Increased LS measured by SWE at any time point regardless of antiviral treatment is associated with an increased risk of HCC in patients with CHB.
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