A comprehensive appraisal of mechanism of anti-CRISPR proteins: an advanced genome editor to amend the CRISPR gene editingopen access
- Authors
- Choudhary, Nisha; Tandi, Dipty; Verma, Rakesh Kumar; Yadav, Virendra Kumar; Dhingra, Naveen; Ghosh, Tathagata; Choudhary, Mahima; Gaur, Rajarshi K. K.; Abdellatif, Magda H. H.; Gacem, Amel; Eltayeb, Lienda Bashier; Alqahtani, Mohammed S. S.; Yadav, Krishna Kumar; Jeon, Byong-Hun
- Issue Date
- Jun-2023
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- anti-CRISPR; genome editing; Acr inhibitors; genetic memory; CRISPR-Cas complex; DNA binding inhibition; DNA cleavage
- Citation
- FRONTIERS IN PLANT SCIENCE, v.14, pp.1 - 14
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS IN PLANT SCIENCE
- Volume
- 14
- Start Page
- 1
- End Page
- 14
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/188402
- DOI
- 10.3389/fpls.2023.1164461
- ISSN
- 1664-462X
- Abstract
- The development of precise and controlled CRISPR-Cas tools has been made possible by the discovery of protein inhibitors of CRISPR-Cas systems, called anti-CRISPRs (Acrs). The Acr protein has the ability to control off-targeted mutations and impede Cas protein-editing operations. Acr can help with selective breeding, which could help plants and animals improve their valuable features. In this review, the Acr protein-based inhibitory mechanisms that have been adopted by several Acrs, such as (a) the interruption of CRISPR-Cas complex assembly, (b) interference with target DNA binding, (c) blocking of target DNA/RNA cleavage, and (d) enzymatic modification or degradation of signalling molecules, were discussed. In addition, this review emphasizes the applications of Acr proteins in the plant research.
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