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Urinary transglutaminase 2 as a potent biomarker to predict interstitial fibrosis and tubular atrophy of kidney allograft during early posttransplant period in deceased donor kidney transplantationopen access

Authors
Kim, Jee YeonWee, Yu-MeeChoi, Monica YoungJung, Hey RimChoi, Ji YoonKwon, Hyun WookJung, Joo HeeCho, Yong MeeGo, HeounjeongHan, MinkyuKim, Young HoonHan, Duck JongShin, Sung
Issue Date
Jul-2019
Publisher
KOREAN SURGICAL SOCIETY
Keywords
Biomarkers; Transglutaminase 2; Kidney transplantation
Citation
ANNALS OF SURGICAL TREATMENT AND RESEARCH, v.97, no.1, pp.27 - 35
Indexed
SCIE
SCOPUS
KCI
Journal Title
ANNALS OF SURGICAL TREATMENT AND RESEARCH
Volume
97
Number
1
Start Page
27
End Page
35
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189481
DOI
10.4174/astr.2019.97.1.27
ISSN
2288-6575
Abstract
Purpose: Transglutaminase type 2 [TG2] is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested whether quantification of urinary TG2 may represent a noninvasive method to estimate the severity of kidney allograft fibrosis.,Methods: We prospectively collected urine specimens from 18 deceased donor kidney transplant recipients at 1-day, 7-day, 1-month, 3-month, and 6-month posttransplant. In addition, kidney allograft tissue specimens at 0-day and 6-month posttransplant were sampled to analyze the correlation of urinary TG2 and kidney allograft fibrosis.,Results: Thirteen recipients had increased interstitial fibrosis and tubular atrophy (IFTA) scores at the 6-month protocol biopsy (IFTA group). The mean level of urinary TG2 in the IFTA group was higher compared to that of 5 other recipients without IFTA (no IFTA group). Conversely, the mean level of urinary syndecan-4 in the IFTA group was tower than levels in patients without IFTA. In the IFTA group, double immunofluorescent staining revealed that TG2 intensity was significantly upregulated and colocalizations of TG2/heparin sulfate proteoglycan and nuclear syndecan-4 were prominent, usually around tubular structures.,Conclusion: Urinary TG2 in early posttransplant periods is a potent biomarker for kidney allograft inflammation or fibrosis.,
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