A visuomotor circuit for evasive flight turns in Drosophila
- Authors
- Kim, Hyosun; Park, Hayun; Lee, Joowon; Kim, Anmo J.
- Issue Date
- Jan-2023
- Publisher
- CELL PRESS
- Keywords
- descending neurons; DNp06; Drosophila; evasive flight turn; LPLC2; threat detection; visual projection neurons; visuomotor circuit
- Citation
- CURRENT BIOLOGY, v.33, no.2, pp.321 - 335.e6
- Indexed
- SCIE
SCOPUS
- Journal Title
- CURRENT BIOLOGY
- Volume
- 33
- Number
- 2
- Start Page
- 321
- End Page
- 335.e6
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/189597
- DOI
- 10.1016/j.cub.2022.12.014
- ISSN
- 0960-9822
- Abstract
- Visual systems extract multiple features from a scene using parallel neural circuits. Ultimately, the separate neural signals must come together to coherently influence action. Here, we characterize a circuit in Drosophila that integrates multiple visual features related to imminent threats to drive evasive locomotor turns. We identified, using genetic perturbation methods, a pair of visual projection neurons (LPLC2) and descending neurons (DNp06) that underlie evasive flight turns in response to laterally moving or approaching visual objects. Using two-photon calcium imaging or whole-cell patch clamping, we show that these cells indeed respond to both translating and approaching visual patterns. Furthermore, by measuring visual responses of LPLC2 neurons after genetically silencing presynaptic motion-sensing neurons, we show that their visual properties emerge by integrating multiple visual features across two early visual structures: the lobula and the lobula plate. This study highlights a clear example of how distinct visual signals converge on a single class of visual neurons and then activate premotor neurons to drive action, revealing a concise visuomotor pathway for evasive flight maneuvers in Drosophila.
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