Fatal outcome of severe fever with thrombocytopenia syndrome (SFTS) and severe and critical COVID-19 is associated with the hyperproduction of IL-10 and IL-6 and the low production of TGF-βopen access
- Authors
- Kang, Su Yeon; Yoo, Jeong Rae; Park, Yejin; Kim, So-Hee; Heo, Sang Taek; Park, Seong Hyeon; Kim, Misun; Kim, Tae-Jin; Oh, Songhyeok; Lee, Moo-Seung; Kim, Jung Mogg; Cho, Nam-Hyuk; Lee, Kyung-Mi; Lee, Keun Hwa
- Issue Date
- Jul-2023
- Publisher
- WILEY
- Keywords
- COVID-19; cytokine storm; IL-10; IL-6; SFTS; TGF-β
- Citation
- JOURNAL OF MEDICAL VIROLOGY, v.95, no.7, pp.1 - 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MEDICAL VIROLOGY
- Volume
- 95
- Number
- 7
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/190682
- DOI
- 10.1002/jmv.28894
- ISSN
- 0146-6615
- Abstract
- Severe fever with thrombocytopenia syndrome virus (SFTSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause the hyperproduction of inflammatory cytokines, which have pathological effects in patient including severe or fatal cytokine storms. To characterize the effect of SFTSV and SARS-CoV-2 infection on the production of cytokines in severe fever with thrombocytopenia syndrome (SFTS) and COVID-19 patients, we performed an analysis of cytokines in SFTS and COVID-19 patients and also investigated the role of interleukin-10 (IL-10) in vitro studies: lipopolysaccharide-induced THP-1-derived macrophages, SFTSV infection of THP-1 cells, and SARS-CoV-2 infection of THP-1 cells. In this study, we found that levels of both IL-10 and IL-6 were significantly elevated, the level of transforming growth factor-β (TGF-β) was significantly decreased and IL-10 was elevated earlier than IL-6 in severe and critical COVID-19 and fatal SFTS patients, and inhibition of IL-10 signaling decreased the production of IL-6 and elevated that of TGF-β. Therefore, the hyperproduction of IL-10 and IL-6 and the low production of TGF-β have been linked to cytokine storm-induced mortality in fatal SFTS and severe and critically ill COVID-19 patients and that IL-10 can play an important role in the host immune response to severe and critical SARS-CoV-2 and fatal SFTSV infection.
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