Association between Micronutrient Intake and Breast Cancer Risk According to Body Mass Index in South Korean Adult Women: A Cohort Studyopen access
- Authors
- Song, Huiyeon; Jeong, Ansun; Tran, Thi Xuan Mai; Lee, Jiseon; Kim, Mikyung; Park, Boyoung
- Issue Date
- Jul-2022
- Publisher
- MDPI
- Keywords
- breast cancer; body mass index; micronutrients; vitamin B6; vitamin C
- Citation
- NUTRIENTS, v.14, no.13, pp 1 - 17
- Pages
- 17
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRIENTS
- Volume
- 14
- Number
- 13
- Start Page
- 1
- End Page
- 17
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/193849
- DOI
- 10.3390/nu14132644
- ISSN
- 2072-6643
2072-6643
- Abstract
- This study investigated the association between micronutrient intake and breast cancer risk in South Korean adult women. This association was stratified according to body mass index (BMI) categories. Data from the Korean Genome and Epidemiology Study (KoGES) and the Health Examinee Study were analyzed. Altogether, 63,337 individuals (aged >= 40 years) completed the baseline and first follow-up surveys; 40,432 women without a history of cancer at baseline were included in this study. The association between micronutrient intake and breast cancer was determined by estimating the hazard ratio (HR) and 95% confidence interval (CI) using the Cox proportional hazard regression model. A stratified analysis by BMI (<25 kg/m(2) and >= 25 kg/m(2)) was performed. The an analysis of 15 micronutrients and breast cancer risk revealed that none of the micronutrients were associated with breast cancer risk after adjusting for covariates. In obese women, the risk of breast cancer was significantly reduced in the group that consumed vitamin C more than the recommended level (HR = 0.54, 95% CI: 0.31-0.93) and vitamin B6 levels above the recommended level (HR = 0.48, 95% CI: 0.25-0.89). In obese women, exceeding the recommended daily intake levels of vitamin C and vitamin B6 was associated with a lower risk of breast cancer. However, other micronutrients were not associated with breast cancer risk in these women.
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