Patterns of Early Neocortical Amyloid- b Accumulation: A PET Population-Based StudyPatterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study
- Other Titles
- Patterns of Early Neocortical Amyloid-β Accumulation: A PET Population-Based Study
- Authors
- Lecy, Emily E.; Min, Hoon-Ki; Apgar, Christopher J.; Maltais, Daniela D.; Lundt, Emily S.; Albertson, Sabrina M.; Senjem, Matthew L.; Schwarz, Christopher G.; Botha, Hugo; Graff-Radford, Jonathan; Jones, David T.; Vemuri, Prashanthi; Kantarci, Kejal; Knopman, David S.; Petersen, Ronald C.; Jack, Clifford R.; Lee, Jeyeon; Lowe, Val J.
- Issue Date
- Jul-2024
- Publisher
- SOC NUCLEAR MEDICINE INC
- Keywords
- amyloid- P; Pittsburgh compound B; PiB; PET; early stage
- Citation
- JOURNAL OF NUCLEAR MEDICINE, v.65, no.7, pp 1122 - 1128
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NUCLEAR MEDICINE
- Volume
- 65
- Number
- 7
- Start Page
- 1122
- End Page
- 1128
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/194920
- DOI
- 10.2967/jnumed.123.267150
- ISSN
- 0161-5505
1535-5667
- Abstract
- The widespread deposition of amyloid- P (A P ) plaques in late -stage Alzheimer disease is well defined and confirmed by in vivo PET. However, there are discrepancies between which regions contribute to the earliest topographic A P deposition within the neocortex. Methods: This study investigated A P signals in the perithreshold SUV ratio range using Pittsburgh compound B (PiB) PET in a population -based study cross -sectionally and longitudinally. PiB PET scans from 1,088 participants determined the early patterns of PiB loading in the neocortex. Results: Early -stage A P loading is seen first in the temporal, cingulate, and occipital regions. Regional early deposition patterns are similar in both apolipoprotein s 4 carriers and noncarriers. Clustering analysis shows groups with different patterns of early amyloid deposition. Conclusion: These findings of initial A P deposition patterns may be of significance for diagnostics and understanding the development of Alzheimer disease phenotypes.
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