Vitamin D deficiency in non-alcoholic fatty liver disease: The chicken or the egg?
- Authors
- Lee, Seung Min; Jun, Dae Won; Cho, Yong Kyun; Jang, Ki Seol
- Issue Date
- Feb-2017
- Publisher
- CHURCHILL LIVINGSTONE
- Keywords
- Non-alcoholic fatty liver disease; Vitamin D; Sunlight exposure
- Citation
- Clinical Nutrition, v.36, no.1, pp.191 - 197
- Indexed
- SCIE
SCOPUS
- Journal Title
- Clinical Nutrition
- Volume
- 36
- Number
- 1
- Start Page
- 191
- End Page
- 197
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/21178
- DOI
- 10.1016/j.clnu.2015.10.017
- ISSN
- 0261-5614
- Abstract
- Background & aims: Serum vitamin D concentration is reduced in patients with non-alcoholic fatty liver disease (NAFLD). Although the mechanism of vitamin D deficiency in liver disease is not fully understood, a few reports have suggested the beneficial effects of vitamin D supplements. The present study investigated changes in serum 25-hydroxy vitamin D level and clinical parameters after total calorie restriction with vitamin D intake reduction in NAFLD patients.
Methods: Newly diagnosed NAFLD patients with elevated aminotransferase levels were chosen for a calorie restriction and weight-reduction program. A total of 82 patients received nutritional education from nutritionists every 2 weeks for 2 months. Serum 25-hydroxy vitamin D level, amount of vitamin D intake, and physical activity were thoroughly investigated.
Results: The mean serum 25-hydroxy vitamin D concentration was 13.0 ng/ml. Twenty-nine patients (35.4%) had severe vitamin D deficiency. Patients with a 25-hydroxy vitamin D concentration <10 ng/ml had an increased risk of abdominal obesity (72.4% vs. 47.2%, P = 0.023) and a higher prevalence of metabolic syndrome (69% vs. 42.2%, P = 0.015) compared with patients with 25-hydroxy vitamin D levels >10 ng/ml. Although total energy and vitamin D intake were reduced during the program, serum 25-hydroxy vitamin D levels increased in patients with NAFLD (P < 0.001). Liver enzymes and metabolic parameters also improved, even as vitamin D intake decreased. Serum vitamin D concentration increased with body weight and intrahepatic fat reduction, independent of decreases in vitamin D intake.
Conclusions: Weight loss per increased serum vitamin D level without vitamin D supplementation and improved metabolic parameters in NAFLD.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/21178)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.